Measurement of TSHR AB and IL-6 Levels and Its Role with Thyroid Dysfunction in Graves ’ disease Patients in Najaf City

Abstract

Graves’ disease (GD) is a common autoimmune disease  that accounts for the majority of cases of hyperthyroidism in the developed world [1] Autoimmune thyroid Graves' disease is one of the most common autoimmune disease (AID), affecting 13 million people and targeting women seven times as often as men. It most often affects young to middle-aged adults but can occur at all ages.[2]. Aim of The study is determination of TSHR Ab levels and IL-6 and its correlation with thyroid dysfunction in  Graves’ disease patients.  A Case - control study was done on 100 patients with GD diagnosed at three hospitals in Najaf city in Iraq, in Al-Sadr Teaching Hospital, Al-Hakim General Hospital, and Al-Najaf Teaching Hospitals, respectively, with group of 32 healthy individual as control. Blood sample was collected from all patients and control. TSHR Ab and IL-6 levels were measured by enzyme-linked immunosorbent assay (ELISA). While TSH, T3 and T4 hormones measured by Cobas e 411 analyzer. The result shown that female (89%) more than male (11%), and the mean age (36.86) were highest than other age. This result explains that TSHR Ab was the main responsible for Grave’s disease. IL-6 were in this study, There were significant levels of TSHR Ab and IL-6 compared to the healthy control group.