PHARMACOLOGICAL PROFILE OF THIADIAZOLE DERIVATIVE: A REVIEW

Abstract

It has long been a fascinating area of research to examine the chemistry of heterocyclic molecules. An essential group of substances for the creation of novel drugs is heterocyclic nucleus 1,3,4-thiadiazole. In recent decades, the synthesis of novel thiadiazole derivatives as well as research into their chemical and biological behavior have become more crucial. A focus of ongoing research in medicinal chemistry is the hunt for antiepileptic substances with higher selectivity and lower toxicity. The pharmacological effects of various classes of thiadiazole compounds, including those with antimicrobial, anticonvulsant, antifungal, anti-diabetic, anti-inflammatory, antioxidant, and other activities, have been the focus of intense research in recent years. A significant global issue is the rise of drug resistance to current treatments.The versatile moiety thiadiazole has a wide range of biological effects.The thiadiazole moiety functions as a "two-electron donor system" and a "hydrogen binding domain." Additionally, it serves as a restricted pharmacophore.