AN OBSERVATIONAL STUDY ON RELATIONSHIP BETWEEN C-REACTIVE PROTEIN ALBUMIN RATIO (CAR) AND NEW-ONSET ATRIAL FIBRILLATION (AF) IN POST-OP CABG PATIENTS

Abstract

Background: The association between systemic inflammatory markers and atrial fibrillation (AF) is an emerging area of interest. This study designed to evaluate the value of prediction  based on C-Reactive protein (CRP) to Albumin Ratio (CAR), C-Reactive Protein, Ratio of Neutrophil-Lymphocyte (N/L), and ratio of Platelet-Lymphocyte (P/L) leading to postoperative AF (New-Onset POAF) occurrence among patients who underwent recent coronary artery bypass grafting (CABG).

Methodology: 306 patients, admitted with coronary artery disease (CAD) and Triple Vessel Disease (TVD) and underwent CABG at SRIHER, Chennai, between August 2022 and 2023, were included. The participants were divided into 2 groups: 1. Patients with normal sinus rhythm (n=187) and patients with New-Onset POAF (n=119). Demographic parameters, clinical parameters, and inflammatory markers were analysed using logistic regression and correlation tests.

Results: CAR is significantly higher along with inflammatory markers like CRP, N/L-ratio, and P/L-ratio in the New-Onset POAF group compared to sinus rhythm group. The logistic regression model revealed that these inflammatory markers were significant predictors of New-Onset POAF. Further correlation tests showed significant positive correlations between markers and New-Onset POAF.

Conclusion: Novel marker, CAR has significant potential in predicting New-Onset POAF in Indian patients who underwent CABG along with Markers of systemic inflammation, including CRP, N/L-ratio, and P/L-ratio. This novel insight underscores the possible role of systemic inflammation in New-Onset POAF development and opens avenues for better risk stratification and therapeutic interventions.