Design and Optimization of Telmisartan Nanosuspension for Improved Drug Delivery

Abstract

This research paper presents the design and optimization of a nanosuspension formulation for Telmisartan, an antihypertensive drug with poor solubility and bioavailability. The nanosuspension was prepared using a solvent evaporation technique with Poloxamer 188 as surfactants and Sodium lauryl sulfate (SLS) as a stabilizer. The formulation was optimized using a Design of Experiment (DoE) approach. The optimized nanosuspension showed a particle size of 73 nm, a polydispersity index (PDI) of 0.183, and a zeta potential of -22.2 mV. Differential scanning calorimetry (DSC) of drug exhibited a change in crystalline form to amorphous. The in vitro drug release studies demonstrated a significant improvement in drug dissolution, with a dissolution rate of optimized nanosuspension formulation (F3) 97.34% in 40 minutes. The developed nanosuspension showed a significant improvement in drug solubility and dissolution making it a promising drug delivery system for Telmisartan with potential clinical applications.