Role of Immunohistochemical Markers in Assessing the Recurrence in Oral Squamous Cell Carcinoma: A systematic Review

Abstract

Abstract:
Detection of recurrence of oral carcinoma at an early stage is the most effective means of
improving survival and reducing morbidity from this disease, yet a significant proportion of
patients succumb to death as a result of recurrence. The literature on immunohistochemical
markers associated with recurrence of oral squamous cell carcinoma (OSCC) was searched
systematically to access relevant data published till 2022. Twenty studies met the inclusion criteria
for the review. In all these studies, the cases of OSCC were analysed histopathologically and then
immunohistochemistry was done. Six studies included immunohistochemistry which was
correlated with PCR. Immunohistochemical markers play an important role in recurrence but the
research in this area is sparse, poorly understood and under-researched. Systematic, high-quality
and theory-driven research in this area is essentially required.