Evaluation of Salivary Nickel Levels in Individuals Receiving Fixed Orthodontic Treatment: An observational study

Abstract

Abstract
Background: This study aimed to evaluate the concentration of nickel in the oral cavity of
individuals undergoing fixed orthodontic treatment.
Materials & methods: The study enrolled two hundred participants below the age of 35,
all slated for extended orthodontic treatment. To assess nickel levels pre and post the
insertion of the permanent orthodontic device, we obtained two samples of stimulated
saliva from each participant. Data analysis was performed using SPSS. Nickel
concentrations in the saliva samples were quantified using an autoanalyzer and reported in
micrograms per liter (µg/L).
Results: The study cohort had an average age of 22.5 years. Initially, participants exhibited
an average saliva nickel level of 6.2 micrograms per liter. Following 15 days of orthodontic
treatment, a modest elevation was observed, with nickel concentrations reaching 14.7
micrograms per liter. These fluctuations over time were found to be statistically significant.
Conclusion: The utilization of fixed orthodontic appliances has been associated with
elevated levels of nickel and chromium in saliva.
Keywords: Orthodontic, Nickel, Saliva