Prospective Assessment of the Effect of Aminophylline Infusion On Renal Function in Critically Ill Adults

Abstract

Abstract
Background: AKI is a sudden decline of kidney function that is frequently associated with high
morbidity and mortality rates. One drug that has been tried with the aim of achieving better AKI outcome
is the use of aminophylline. Because studies involving adults are few, little is known about the efficacy
and outcome of aminophylline therapy in AKI. However, the data that support the use of aminophylline
in this patient population is not well established. So aim of this clinical trial is to assess the hypothesis
that aminophylline improves renal function in critically ill adults. Method:This was 1000 bedded
multispecialty hospital -based Prospective, open label, single arm study group conducted among 80 cases
to the Department of Critical Care, in Meenakshi Mission Hospital and Research Centre, India, From
March 2020 to February 2021 and after obtaining clearance from the institutional ethics committee and
written informed consent from the study participants.Results: In our study, all 80 cases had statistically
significant increase in urine output in mean time of 8 hours. 81% of cases improved without RRT. 61% of
the cases had more than 30% increase in eGFR from pre-treatment levels. Inotropes requirements stopped
in 62.5% of the cases following aminophylline infusion. Cases requiring positive pressure ventilation
requirement decreased from 75% to 13.8%. Only 6.3% cases required RRT. 5% of cases expired due to
underlying disease. No adverse events noted. Conclusion:Based on the above results, it is evidenced that
aminophylline improves renal function in critically ill patients. It may help in reducing the stay in ICU by
early weaning from ventilator and inotropes as seen in our study. It helps in mitigating cost for the patient
by reducing stay and avoiding RRT. There were no side effects associated with it when used in low dose
as in our study. So that it can be safely used in resource limited setting. It helps in reducing mortality by
reducing incidence of progression of AKI and other associated complications.
Keywords:AKI, Kidney, Aminophylline, Adults.