INTRALESIONAL INJECTION OF 5-FLUOROURACIL IN COMBINATION WITH TRIAMCINOLONE ACETONIDE IN KELOID TREATMENT

Abstract

Objective: to evaluate the efficacy of 5-Flurourasil (5-FU) and Triamcinolone Acetonide (TAC) injection combination in the management of Keloids.

Methods: Thirty patients with the diagnosis of keloid were treated with a combination injection of 5-FU & TAC. Objective assessments were done. Scar scales were assessed at baseline, 1 month, & 1 year follow-up.

 Results: Ultrasound measurements shows a significant decrease in volume (baseline mean score: 1,105 911.5 mm3, 1-month follow up mean score: 416.1 218.1 mm3, 1-year follow-up mean sore: 431.2 253.6 cu. , P= <0.0001, respectively) and penetration depth of keloids (relative reduction between baseline and 12-month FU of 74.4%, P= <0.0001). The patient & observer scar assessment scales (POSAS) also show objective & subjective improvement in keloid size.

 Conclusion: 5-FU in combination with TAC intralesional injection is effective for keloid management.