Screening of the Anticancer Potential of Lycopene-Loaded Nanoliposomes

Abstract

Lycopene, a naturally occurring triterpene, demonstrates significant anti-cancer potential. However, due to its limited bioavailability, it exhibits a diminished solubility in an aqueous environment. A promising technique for enhancing the solubility and bioavailability of Lycopene is the utilization of liposomal nano formulation. The present investigation involved the development of Lycopene nanoliposomes, followed by a comprehensive analysis and modification of their physical and chemical properties. Lycopene nanoliposomes exhibited favorable attributes for their prospective application in drug administration, as evidenced by their particle size distribution spanning 40-150 nm, zeta potential of -21.5mV, and an entrapment efficacy of 60.0%. The cytotoxic efficacy of a liposomal nano formulation loaded with Lycopene was established in inhibiting cancer cell proliferation, as evidenced by its impact on the A-549, MCF-7, and Hela cell lines. Consequently, the present study endeavor demonstrated the potential utility of Lycopene nanoliposomes as a viable nano formulation for the treatment of cancer.