Effect of Aspirin and Nicotinic Acid Derivative As Potential Hypocholesterolemic Agents

Abstract

INTRODUCTION:
Atherosclerosis is characterized by the deposition of cholesterol esters and other lipid in the connective tissues of the arterial wall. Aspirin has long been used as an effective analgesic for pain, inflammation and fever (Treacher, et al, 1978; Vane,J.R,1971). This strongly suggest that the relative activities of these two substances are the determining factors whether or not a clot will form (Bergman, et. Al. 1981; Ekdund, et. al. 1981).

MATERIAL AND METHODS:

All experiments are carried out on healthy rabbits weighing 1.5 2.0 kg. Rabbits are classif ied into the following four groups, each group comprised of 4 rabbits: Test for the fevèl of cholesterol is done a follows: Serum is separated by centrifuging the blood at 4000 R.P.M., in Heraus centrifuge. 0.1 ml sample of serum was taken into tubes and treated according to instruction sheets for manual assay provided by Boheringer Mannheium, kit No. 124095 (West Germany) and measured on spec trophotometer (Spec tronic-21). Control sera were used from Boheringer Mannheium (West Germany). All the chemicals used are of an& it ical and reagent grade supplied by Merck.

RESULT:
Results are summerized in Table-1 and 2. Table-1 shows the level of serum cholesterol (mg/lOOrnl) in all the groups of rabbit before the treatment of drugs i.e for 120 days.

DISCUSSION:
It has been shown that during the feeding of an atherogenic diet containing 2% cholesterol and 10% butter for 5 months caused narrowing of the coronary and peripheral arteries which may produce lesion (Ross et. al. 1976) due to the subendothelial injury, platelet aggregation may result by the action of enzyme prostaglan din synthetase.