Predicting the Severity of Left Ventricular Dysfunction with Mitral Regurgitation, Left Ventricular Diastolic Dysfunction and Right Ventricular Dysfunction Among Dilated Cardiomyopathy Patients.

Abstract

Objective

The aim is to evaluate the LV diastolic dysfunction, grading the severity of mitral regurgitation and right ventricular dysfunction in dilated cardiomyopathy patients with severe left ventricular systolic dysfunction (LVEF < 30%) which helps to predict the cardiovascular mortality.

Methodology

This study was conducted among 66 patients, aged over 25yrs with electrocardiographic evidence of dilated cardiomyopathy. Clinical examination and electrocardiography was to assess the status of mitral regurgitation, left ventricular diastolic dysfunction and right ventricular dysfunction. Ejection fraction was measured by Simpson’s method - qualitatively evaluated.

Result

The study showed, 53% patients had diastolic dysfunction, 62% patients had mitral regurgitation and around 50% patients had right ventricular dysfunction. Mitral regurgitation and diastolic dysfunction are correlated with the severity of LV systolic dysfunction through LVEF with a significant P - value of 0.004 and <0.001 respectively. However, right ventricular dysfunction parameters does not correlate with severity of LV systolic dysfunction but has a major clinical importance is management of and treatment of DCM.

Conclusion

In our study, the    mitral regurgitation and diastolic dysfunction are correlated with severity of LV systolic dysfunction. Detailed assessment of these parameters in DCM patients - severe LV systolic dysfunction helps in aiding treatment and to predict the cardiovascular mortality.