Role of Some Immunological Markers in Iraqi Patients with Rheumatoid Arthritis and Salmonella Typhoid

Abstract

The study aimed to investigate the role of some immune indicators in Iraqi patients with rheumatoid arthritis and Salmonella typhi.  The current study was conducted on a sample of Iraqi patients with rheumatoid arthritis and Salmonella typhi, as blood samples were collected from 60 patients with rheumatoid arthritis and infected with Salmonella typhi bacteria with ages ranging between 21-70 years, the number of females was more than the number of males with a significant difference of  P<0.001 where the number of  females was 55 and by 91.7% while the number of males was 5 and by 8.3%. For the purpose of comparison, 28 other blood samples were collected from healthy people (healthy control) ranging from Between 21-60 years, the number of males was 5, by 17.9%, and the number of females was 23, by 82.1%. The association between several immune markers and rheumatoid arthritis and Salmonella typhi was also studied, includingcyclic citrullinated peptides antibody anti, alpha 1 alpha, alpha  albineoplasmosis 33, alpha albicanosis 36 alpha, IgG immunoglobulin and  IgM immunoglobulin.  The results indicated a statistically significant increase (P<0.001) in the concentration of Cyclic citrullinated peptides antibody in blood  samples of rheumatoid arthritis patients and Salmonella typhi patients compared to healthy control sample, where the average blood protein in a patient sample was 406.62 mg/L compared to 66.07 mg/L in a healthy control sample.  And that there was a significant increase (P<0.001) in the level of interneuloidal 1 thousand in the blood sera of the patient sample compared to its level in the blood serum of the healthy control sample. The concentration of these antibodies in the blood sera of the healthy control sample was 1.36 U/ml compared to 2.87 U/ml in a sample of patients with rheumatoid arthritis and Salmonella typhi. The results also indicated a high significance (P<0.001) in the concentration of interleukid-33 in the blood serum of a sample of rheumatoid arthritis patients and Salmonella typhi patients compared to healthy control, where the average concentration was 19.09 mg/dL in the patient sample and 8.18 mg/dL in the healthy control sample<. ) in the interneoplasmic rate of 36 thousand in blood serum of samples of rheumatoid arthritis patients and Salmonella typhi patients, which is 284.65 compared to the healthy control sample, which is 238.59  ng/l. The results indicated a statistically significant increase (P<0.001) in the serum rate of IgG immunoglobulin in  the  blood serum of samples of rheumatoid arthritis patients and Salmonella typhi, which is 3.39 (ug/ml). ) compared to the healthy control sample of 0.72 (ug/ml). This indicates that these immune indicators above can be considered very important immunological indicators for the diagnosis of rheumatoid arthritis.