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Introduction: A tiny fraction of diabetics develop normoalbuminuric chronic kidney disease (NACKD), a progressive renal insufficiency without albuminuria. India has little studies on this topic. This study sought to discover normoalbuminuric renal impairment prevalence and clinical correlations in diabetic Indians.
Methods: A north Indian tertiary care center conducted a retrospective review of type 2 diabetes mellitus patients' medical records. People were classified as having "no kidney disease (NKD)", "chronic kidney disease (CKD)", "albuminuria alone (ALB)", "normoalbuminuric low e-GFR (NACKD)", or "albuminuric CKD (ACKD)". These groups were compared clinically and biochemically.
Results: 537 patients met study criteria. NACKD and ACKD had longer diabetes than NKD (p<0.001). ACKD had greater hypertension and dyslipidemia than NACKD and NKD (p<0.05 and p<0.001, respectively). ACKD had a greater diastolic blood pressure than NKD (p<0.05). NACKD patients have more coronary artery disease than ACKD patients, but their medical histories are otherwise similar.
Conclusion: These findings reveal that NKD and NACKD patients differ clinically and biochemically from ACKD and renal disease-free persons. Since medical conditions might impact CKD's course and prognosis, these variances may affect patient management and treatment. Thus, more research is needed to assess these changes' impact on patient outcomes.
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