Haematological Indicators in Primary Hyperparathyroidism an Original Research

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Dilip P. Patil, Aparna P. Patange


Introduction: An endocrine condition known as "Primary Hyperparathyroidism (PHPT)" is characterised by increased levels of the hormone "Parathyroid Hormone (PTH)" and serum calcium. Haematological indicators have changed in patients with PHPT, according to several research. Data on the haematological markers in PHPT patients in the Chinese community are, however, scarce. The purpose of this study was to examine the haematological variables in Chinese patients with PHPT.

Methods: This study comprised 64 patients with a PHPT diagnosis in total. Before surgery, haematological measurements were made of the "Red Blood Cell Count (RBC)", "Haemoglobin (Hb)", "Hematocrit (HCT)", "Mean Corpuscular Volume (MCV)", "Mean Corpuscular Haemoglobin (MCH)", "Mean Corpuscular Haemoglobin Concentration (MCHC)", and "Red Cell Distribution Width (RDW)". PTH and serum calcium levels were also assessed.

Results: The mean age of the patients was 56.5 ± 11.6 years, and 73.4% of the patients were female. The mean duration of the disease was 3.9 ± 2.5 years. The preoperative serum calcium levels ranged from 2.6 to 3.3 mmol/L, with a mean of 2.9 ± 0.2 mmol/L. The serum PTH levels ranged from 120 to 1200 pg/mL, with a mean of 435 ± 248 pg/mL. The results showed that patients with serum calcium levels below 2.75 mmol/L and serum PTH levels above 500 pg/mL had significantly lower RBC count, Hb level, and HCT than patients with higher levels. However, there were no significant differences in MCV, MCH, MCHC, or RDW between the different groups.

Conclusion: Haematological indicators were observed to be impacted in Chinese individuals with PHPT, particularly in those with lower serum calcium levels and higher PTH levels. These findings imply that haematological markers may be crucial diagnostic and therapeutic indicators for PHPT

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