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Study aimed to evaluate the effectiveness of the educational program on nurse's knowledge about hydatidiform mole methods: The nurses were exposed to pre-test, implementation of program, post – test 1 immediately after the application of the program, and the post-test 2 was done after two weeks from the first post-test. Results: nurses show a fair level of knowledge during the pre-test (Mean score= .44) , the post-tests 1 and 2, the nurses show a good level of knowledge (Mean score= .98 and .92) . Conclusion: The level of nurses’ knowledge related to practices about hydatidiform mole pregnancy”; shows fair level of knowledge in the items during the pre-test. While during the post-tests 1 and 2, the nurses show a good level of knowledge among all items. Recommendation: Nurses that work in the maternity units should update their knowledge through training courses about hydatidiform mole
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