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Aim: To study the effectiveness comparison of general anaesthesia and spinal anaesthesia for laparoscopic cholecystectomy. Materials and methods: 120 patients were split into two groups at random: the SA group (Group 1) and the GA group (Group 2). Patients who were randomly assigned to the SA group were premedicated with injections of ondansetron 0.1 mg/kg and midazolam 1 mg 30 minutes before to the surgery after determining that the pre-anaesthetic assessment was satisfactory. Patients in the GA group received IV injections of ondansetron 0.1 mg/kg, glycopyrrolate 0.2 mg, midazolam 1 mg, and tramadol 2 mg/kg as premedication. Results: There were no significant differences in age, weight, gender and duration of surgery between the groups. The post-operative pain levels between the GA and SA groups showed a significant mean difference. At all time intervals shown in Table 2 observations, the repeated measure ANOVA reveals that pain ratings in the GA group are substantially higher than those in the SA group. According to reports, post-operative discomfort was minor and was readily manageable in the SA group. In contrast to the GA group, where 55 patients (91.67%) received nalbuphine 0.1 mg/kg IV treatment and 5 patients (8.33%) received tramadol 50 mg IV, it was successfully controlled with diclofenac sodium 75 mg IM in 55 patients (91.67%) and tramadol 50 mg IV in 5 patients (8.33%). Conclusion: This research demonstrates that spinal anaesthesia is also a suggested alternative to the traditional use of general anaesthetic in open cholecystectomy. Traditionally, general anaesthesia is used. Therefore, it is safe and more effective than general anaesthetic in providing a lengthier post-operative pain-free time, less of a necessity for analgesics or opioids, and no respiratory issues that have been recorded.
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