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Background: General anesthetic induction agents may decrease arterial blood pressure via myocardial depression, vasodilatation and attenuation of autonomic nervous activity. The present study was conducted to find hemodynamic changes and complication occurring with Propofol and Etomidate during general anaesthesia. Materials & Methods: 70 patients who were schedule to undergo surgical procedure under general anaesthesia of both genders were divided into two study groups Group I: 35 patients who received Propofol, and group II 35 patients who received Etomidate group. All the hemodynamic parameter was recorded during the surgery procedure. Results: Group I had 20 males and 15 females and group II had 16 males and 19 females. The mean heart rate (beats/min) at baseline was 86 and 87, at induction was 87 and 88, at laryngoscopy was 88 and 90, at one minute was 90 and 91, at five minutes was 88 and 89 and at fifteen minutes was 89 and 88. The mean arterial pressure (mm Hg) at baseline was 92 and 95, at induction was 102 and 88, at laryngoscopy was 96 and 90, at one minute was 98 and 94, at five minutes was 88 and 91 and at fifteen minutes was 94 and 90 in group I and II respectively. Conclusion: Etomidate found to be superior in comparison to propofol as an anaesthetic agent.
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