ACE Polymorphisms Rs (4343) and Its Association with Ace Enzyme in Some of Patients with Diabetic Nephropathy in Some Population of Salah Al-Din Governorate in Iraq

Main Article Content

Muhanad Jassam Mohammed ALkafaji, Adel Fawzy Shehab, Hadeel A. Omair


The study was designed to investigate the relationship of ACE gene and serum ACE level in a sample of patients with diabetic nephropathy .This study was conducted on (110) blood samples of people with diabetic nephropathy, with (42) samples from healthy people as a control group. The results showed rise in serum ACE level, as it reached (114.59 ± 1.88 U/L) in patients and molecular study showed, after DNA extraction and the use of Real-Time PCR technology for the(ACE)  rs4343 gene in patients with diabetic nephropathy and healthy people showed the presence of alleles (A, G) with the appearance of three genotypes, which are (AA, AG, GG). The frequency of the AA genotype is (0.236) the AG genotype is (0.3) and the GG genotype is (0.463) and the value was (OR = 0.66, 95% CI = 0.33 – 1.47) in patients with diabetic nephropathy. The frequencies of the two alleles, A and G, were as follows: for the G allele it was (0.65). and allele A is (0.35). and the( OR = 1.053 , 95% CI = 0.84 – 1.21)

Article Details