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Wound swab samples that were obtained from infected wounds were used for the isolation and identification of bacterial isolates based on their appearance and biochemical properties. Staphylococcus aureus, gram-negative bacteria, and other gram-positive bacteria. Using the disk diffusion method, antibiotic susceptibility tests for S. aureus isolates were conducted against several antibiotic types. The results showed varying levels of resistance to various antibiotics; the ones with the highest level of resistance were chosen for more research. Meanwhile, zinc sulfide nanoparticles were synthesized using a quick and affordable green technique that used pomegranate peel extract. By using accepted techniques, the phytochemicals in pomegranate peel extract were tested. The outcomes confirmed that it contains flavonoids. These components served as capping, stabilizing, and reducing agents for ZnSNPs. The size and morphology of ZnS NPs were characterized by using Scanning electron microscopy (FE-SEM), UV-Vis spectrophotometer, atomic force microscopy (AFM), X-ray Diffraction analysis (XRD), and the results were 40nm, 270nm, 20nm, 90nm respectively. Evaluation of the synergistic effect of the synthesized nanoparticles revealed that the antibiotic activity. (Ciprofloxacin, azithromycin, tetracycline, gentamycin, and penicillin) enhanced in the presence of ZnS nanoparticles against pathogenic isolates chosen for the analysis.
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