THE IMPACT OF THERAPEUTIC AND LIFESTYLE MODIFICATION OUTCOMES ON METABOLIC RISK MARKERS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Abstract

Metabolic syndrome is a condition characterized by a group of risk factors that increase the risk of cardiovascular disease and type 2 diabetes. Metabolic syndrome is a constellation of interrelated risk factors with mostly promote atherosclerotic cardiovascular disease.

Methods:  Patients were assigned randomly in eight groups based on the plan of study. Various health indicators compared include weight, BMI, systolic and diastolic blood pressure, fasting blood sugar, glycated hemoglobin, triglycerides and HDL.

Results: We found the risk of hypertension was 23% lower in females than males with metabolic syndrome. No other parameter had correlation with gender. When comparing among the groups for the parameters; group 5 had higher mean values of weight and BMI than group 1, the two groups had significant impact on weight BMI, blood pressure, glycemic parameters. Group 1 had lower mean values of triglycerides and HDL than group 5. Group 7 was more effective than group 3 in reducing weight and BMI, group 7 was associated with lower blood pressure, glycemic parameters and higher HDL than group 3.

Conclusion: Overall our study concluded that lifestyle modification is necessary in improving all parameter compared with other groups, with augmented effect upon pharmacological intervention. The effect was significant in groups without metabolic syndrome.