In-Silico Study of the Antioxidant Ability for 4-thiazolidinone Analogs Using DPPH assay

Abstract

Oxidative stress and related diseases resulting from the overproduction of free radicals can be counteracted by designing and developing novel antioxidative agents that can protect the human body against the damage caused by free radicals. The present study, A series of new 4-thiazolidinone derivatives were synthesized by reacting (S, E)-4-(4-(2-(4-substituted benzylidene) hydrazinyl) benzyl) oxazolidin-2-one with thioglycollic acid. The intermediate (S, E)-4-(4-(2-(4-substitutedbenzylidene) hydrazinyl) benzyl) oxazolidin-2-one were synthesized by condensation of (S)-4-(4-hydrazinyl benzyl) oxazolidin-2-one with different aryl benzaldehydes in the presence of ethanol. All the newly synthesized compounds were assigned on the basis of IR, ¹H NMR and ¹³C NMR spectral data. All the newly synthesized compounds were evaluated for in-vitro antioxidant activities by using DPPH radical scavenging assay models. Most of the synthesised compounds showed good antioxidant activity.