Development and Characterization of Nanogels-Based Formulation for Topical Delivery of Heparinoid

Abstract

In recent years, there has been a growing interest in the development of advanced drug delivery systems to enhance the efficacy and therapeutic outcomes of topical medications. Heparinoids, a class of glycosaminoglycans with potent anti-inflammatory and anticoagulant properties, hold immense potential for various dermatological conditions. This study aims to address this limitation by designing and characterizing a novel nanogels-based formulation for the efficient topical delivery of heparinoids.The nanogels were prepared using a biocompatible and biodegradable polymer matrix, chosen to improve the solubility and stability of the heparinoid drug. The physicochemical properties of the nanogels, including particle size, zeta potential, drug encapsulation efficiency, and in vitro drug release kinetics, were comprehensively characterized using advanced analytical techniques.The results demonstrated that the nanogels exhibited excellent colloidal stability, sustained drug release behavior, and enhanced skin permeability, surpassing the limitations associated with traditional heparinoid formulations. Further in vivo studies and clinical investigations are warranted to validate the translational potential of this nanogels-based formulation for topical delivery of heparinoid drugs.