Imaging Methods Applicable in the Diagnostics of Alzheimers Disease, Considering the Involvement of Insulin Resistance with Clinical Pharmacological Point

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Hossein Tahernia, Mohammad Ghasemian, Fatemeh Rostami, Sara Hassani, Majid Khalilizad


 The fact that Alzheimer's disease is related to impaired insulin signaling and glucose metabolism in the brain is widely known, and for this reason it has been said that Alzheimer's disease is a special form of diabetes and it is called type 3 diabetes.

Materials and methods:

This experimental study was conducted in 1402 at the University of Medical Sciences. A total of 60 people were diagnosed with Alzheimer's disease using imaging methods, also people were examined for diabetes and diabetic people were included in this research. The effect of insulin resistance on Alzheimer's disease was investigated using imaging methods. The data of the present study were collected and one-way ANOVA and (Tukey's post hoc test) were used to analyze the data. Also, a significance level of P<0.05 was considered.


 The pathological symptoms of Alzheimer's disease are the appearance of intracellular phosphorylated tau proteins and extracellular beta amyloid plaques, which are created by beta and gamma secretase enzymes from the amyloid precursor protein.  Amyloid beta and phosphorylated tau proteins cause local poisoning of neurons and eventually lead to the death of neurons and the occurrence of Alzheimer's disease.  Therefore, early diagnosis of Alzheimer's disease plays an important role in reducing its complications.

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