COMPARISON BETWEEN CYCLOOXYGENASE, PROSTAGLANDIN LEVEL, AND PAIN SCORE IN IBUPROFEN AND PARACETAMOL ADMINISTRATION AS PREEMPTIVE ANALGESIA DURING LAPAROTOMY

Abstract

Objectives: Preemptive analgesia has potential to be more effective than the same analgesic therapy given after surgery because of its protective effect on the nociceptive system. The purpose of this study was to analyze the comparison of cyclooxygenase levels, prostaglandins and postoperative pain scores 2 hours, 6 hours and 24 hours in the administration of ibuprofen and paracetamol as preemptive analgesia in patients undergoing abdominal surgery under general anesthesia at Integrated Surgery Center (GBPT) of Dr. Soetomo Hospital.

Methodology: Analytical study, quasy experimental, prospective. A total of 60 patients with PS ASA 1-3 aged 18-60 years who underwent laparotomy were recruited in this study. In this study, one of the paracetamol, ibuprofen, or control groups was given a 100 ml PZ placebo in the premedication room before anesthesia was performed. The three groups were treated the same under anesthesia and blood was drawn 1 hour after administration of preemptive analgesia to check cyclooxygenase and prostaglandin levels. After the operation was completed, postoperative pain scores were examined at 2 hours, 6 hours and 24 hours.

Results: In this study there were significant differences in the analysis of cyclooxygenase values, the highest was the control group, followed by paracetamol and the lowest was the ibuprofen group (p value = 0.000). There was a significant difference in the analysis of prostaglandin values, the highest was in the control group, followed by paracetamol and the lowest was in the ibuprofen group (p value 0.000). Significant differences were found in the analysis of postoperative pain scores 6 hours (p value 0.004) and 24 hours (p value 0.043), the highest pain score was in the control group, paracetamol, followed by ibuprofen, while the analysis of postoperative pain scores 2 hours found no significant difference (p value = 0.415).

Conclusion: Patients who received preemptive analgesia (ibuprofen or paracetamol) had lower cyclooxygenase, prostaglandin and postoperative pain scores