Formulation and Evaluation of Fast Dissolving Telmisartan Tablets

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Mohd Arsh, Jaya Martolia, Bhupendra Kumar


Rapid response is crucial in such situations since individuals with sudden increases in blood pressure have significantly reduced functional abilities and are very restless. Therefore, utilising a fast dissolving drug delivery mechanism would help the patients receiving acute treatment. Because telmisartan, an anti-hypertensive medication, is insoluble in water, it may dissolve slowly or not at all in the gastrointestinal tract. Because of this, the rate of dissolution is slower, and its bioavailability is lower (42%). In this study, an effort has been made to get ready. Superdisintegrants Crosscarmellose Sodium, Doshion, and Sodium Starch Glycolate are added to Telmisartan tablets in order to speed up the drug's release from the dosage form, hence increasing the drug's bioavailability. The blend and tablets were made using direct compression techniques, and their physicochemical characteristics and dissolution study were assessed. Weight variation, thickness, hardness, disintegrating time, wetting time, and an in-vitro drug release and stability study were among the evaluation tests carried out. The concentration of Superdisintegrants was added, which lengthened the time it took for Fast Dissolving Tablets to dissolve.

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