Analgesic and Anti-inflammatory Activities of Isatin Derivatives-A Review

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Shobhit Shrivastava, Dharmendra Ahuja


Due to the increasing frequency of inflammatory illnesses and the rising costs to the global healthcare system as a result of longer life expectancies, these conditions have attracted a lot of attention. Corticosteroids and non-steroidal anti-inflammatory medicines, which are linked to a variety of side effects and toxicity risks, are often used in the long-term treatment of chronic conditions. Many investigators have committed their orientation to discovering and developing potent anti-inflammatory medications with minimal to no adverse effects. The effects of isatin are varied, making it a versatile substance. In addition to its effects on COX1, COX2, and other inflammation and analgesic-inducing precursors, isatin has been discovered to have many biological activities like anticonvulsant, antimicrobial, anti-neoplastic, anti-hypertensive, anti-tuberculosis, anti-HIV, antiulcer, and antiviral etc. In this study, we reviewed a few isatin derivatives that had been reported to have anti-inflammatory and analgesic properties and hence might be sources of anti-inflammatory drugs. This review study's objective was to offer some pertinent data for the creation of secure and efficient anti-inflammation and analgesic medications.

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