Synthesis, Characterization and Antioxidant Activity Some of Novel Isatin‑Based N-Mannich Bases

Abstract

Free radical or reactive oxygen species (ROS) damage healthy cells in many ways and may cause various diseases like cancer, diabetes, cardiac disorders etc. Antioxidants play a significant role in improving immunity and preventing tissue damage by free radicals. A new series of isatin based N-mannich bases derived and synthesized the MM1-9 derivative for their antioxidant activity. The DPPH method was used to screen the antioxidant activity of these compounds using ascorbic acid. The results revealed that compound MM4 (3-{[6-(benzylideneamino)pyridin-2-yl]imino}-1-(morpholin-4-ylmethyl)-5-chloro-indolin-2-one) showed the highest IC₅₀ values amongst the tested compounds. This may be probably due to electron withdrawing and the morpholine substituent on isatin.