Assessing Visual related Quality of life in Sickle Cell Disease Patients in Al-Ahsa, Saudi Arabia

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Saif Khuzaim Al-Dossary1


Background: Sickle cell disease (SCD) can lead to ophthalmic complications that impair quality of life. Visual disability in Saudi SCD patients is not well-characterized.

Aim: This study assessed vision-related quality of life and associated factors in SCD patients in Saudi Arabia.

Methods: This cross-sectional study included 100 adults with SCD evaluated at a hospital in Al-Ahsa. The National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) was administered to assess vision-specific QOL. Clinical and demographic data were also collected.

Results: Mean NEI VFQ-25 composite score was 75, indicating moderately reduced QOL related to vision. Older age was associated with higher VFQ-25 scores (p=0.021). Longer disease duration and transfusion history showed no significant correlations. Hydroxyurea use was linked to higher scores (p=0.012).

Conclusion: SCD patients have visual disability that impairs QOL. Routine eye evaluations and hydroxyurea therapy may optimize ocular health.

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