Acute Haemoclynamic Effects Of Intravenous ICI 153,110 In Congestive Heart Failure

Abstract

Summary
Despite recent advances in the pharmacological and mechanical means of supporting ventricular function, congestive heart failure continues to be major cause of morbidity and mortality. Impaired myocardial contractility remains to be a primary feature. Phosphodiesterase inhibition can lead to an increase in cyclic AMP and augment myocardial contractility. The results in this study suggest that the positive inotropic drug may be beneficial for the treatment of Congestive heart failure. Furthermore ICI 153, 110 proves to be effective positive inotropic drug with vasodilating effects and does improve left ventricular per- formance during acute administration in patients with congestive heart failure.

Introduction:
The present study was designed to evaluate the haemodynamic effects of IC! 153, 1 10, a phosphodt esterase inhibitor in patients with NYHA class III congestive heart failure. Haemodynamic effects were evaluated by right and left heart catheter.
Nine patients were studied with mean age of 65.1 years. Heart rate remained unchanged. Syst emic vascular resistance decreased from mean of 22 to 17while cardiac output increased from 4.5 to
5.1. Left Ventricular dpldt increased from 953 mmHg/sec to 1245 mmHg/sec. Left ventricular End diastolic Pressure fell from 21 mmHg to l4mmHg.