A Study of Biogenic Amines In Central Aortic And Coronary Sinus Blood In Ischemic Heart Disease

Abstract

Introduction:
Increased sympathetic activity is postulated to be an important determinant of the pathophysiological events associated with ischemic heart disease. Increased peripheral catecholamine concentrations have been documented in acute myocardial infarction’4 and in angina pectoris^5-6.

Methods:
The study group consisted of 26 patients undergoing coronary angiography for evaluation of angina. The control group consisted of 6 patients of suspected angina who were admitted in intensive care unit, but subsequently on investigations were found to have non-cardiac cause for their chest pain and angiographic evidence of normal coronary arteries.

Discussion:
Angina pectoris is generally associated with pain and emotion and a rise of plasma catecho1am-ines is expected in such patients. But reports of their levels in arterial blood have been variable^{5’6’7’9’1011}. .“ attempt at measuring their levels in coronary sinus blood has not much solved this confusion’2’13. The response to pacing has similarly been variable¹².