Acute Effects of Anti-Anginal Drugs on Cardiac Pacing Threshold

Abstract

SUMMARY:
Forty cardiac pacing threshold studies were conducted in 25 patients being temporarily paced prior to permanent pacemaker implantation using the following anti-anginal drugs: Nitroglycerine 0.5 mg (7 patients), nifedipine 10 mg (7 patients) administered sublingually and intravenously administered (W) oxyfedrine 0.15 mg/kg (6 patients), propranolol 0.1 mg/kg (10 patients), and verapamil 0.15 mg/kg (10 patients). Changes in voltage (volts), current (mA), energy (micro-joules) and resistance (ohms) were measured using a pacemaker system analyser at a constant pulse width (0.6 msec.) and pacing rate.